Genesis Rodriguez was born in 1987 in Miami, Florida. Her mother is Carolina Perez is Cuban and her father is Jose Luis Rodriguez “El Puma,” a known Venezuelan actor and singer.  She attended Carrollton School of the Sacred Heart in Miami and participated in school productions.

She attended acting courses in New York and in California. When she returned to Miami, Florida she continued private instruction and starred in the American daytime series Days of Our Lives from November 2005 through January 2006 and was also a special guest on the Bravo TV series Top Chef.

She has starred in the English and Spanish TV shows Prisionera in 2004, Dame Chocolate in 2007,  Doña Bárbara from 2008 to 2009, Entourage from 2010 to 2011, Time After Time in 2017. She has obtained roles in films as well-  Man on a Ledge in 2012, Casa de Mi Padre  with comedian Will Farrell in 2012, What to Expect When You’re Expecting  in 2012, The Last Stand in 2013, Tusk in 2014 and Run All Night and 2015. She did the voice for Honey Lemon, a character in Disney’s animated film Big Hero 6.